Clinical Research at UCSF Epilepsy Center

UCSF Epilepsy Research

Research plays a key role in shaping our clinical practice of the UCSF Epilepsy Center. Our current program consists of a broad variety of research projects reflecting the full range of clinical and surgical activity in the program.

P.O.E.M Study

The Human Epilepsy Project (HEP)

Neocortical Epilepsy Surgery Trial
STRIVE online survey


Epilepsy Phenome/Genome Project (EPGP)

A national, multicenter study aimed at collecting detailed phenotypic and genomic information on patients with idiopathic generalized epilepsy (IGE), localization-related epilepsy (LRE), crytptogenic infantile spasms (IS), cryptogenic Lennox-Gastaut Syndrome (LGS), and cryptogenic malformations of cortical development (MCD). The goal is to enroll 750 sibling pairs with IGE, 750 sibling pairs with LRE, 1500 controls for the sibling pairs, 250 IS probands and their parents, 250 LGS probands and their parents, and 250 MCD probands and their parents (total number of patients/controls = 6,750 over five years). The aim of the study is to identify multigenic determinants of the underlying epilepsy syndrome and pharmacoresponsiveness or pharmacoresistance.

End date: 4/30/12

Contact: Maritza Lopez, 415.353.2437

Pregabalin in Children with Partial Onset Seizures

The first part of this study is a seven-day phase evaluating the safety and tolerability of pregabalin compared with placebo. Upon completion of this initial phase, there is a 12 month open-label extension phase to also evaluate the safety and tolerability of pregabalin in children with partial onset seizures.

Contact: Janna Klein, 415.353.9376

4T imaging study
The purpose of this study is to assess the clinical utility and optimal techniques for localizing a seizure focus utilizing 4T magnetic resonance imaging.

Ongoing through 2011

Contact: Paul Garcia, 415.353.2437

Epilepsy and Emotion: Psychophysical responses to visual stimuli (CLOSED)

The purpose of this study is to investigate potential emotional deficits in patients with mesial temporal sclerosis utilizing psychophysiological responses during a visual stimulus paradigm.

Contact: John Hixson, 415.353.2437

Progesterone therapy for women with epilepsy

This study examines whether using progesterone in a cyclical fashion as an adjunctive therapy is effective in women with medically refractory localization-related epilepsy.

We hope to be recruiting women with epilepsy for this study sometime in the late summer/early fall.

Contact: Tina Shih, 415.353.2437

The Effect of Epilepsy Surgery on Social Cognition (CLOSED)
This study is currently in year 5 of 5, examining social cognition in people with intractable epilepsy before and after resective surgery (3m, 1y, 2y).

Contact: Heidi Kirsch, 415.353.2437

Seizure dynamics
This is an ongoing exploratory analysis of ictal electrocorticography patterns using a variety of modeling technique. This study involves extracting and anonymizing electrocorticography epochs containing seizures, pre-ictal periods, and baseline periods, and then comparing these to mathematical models.

Contact: Heidi Kirsch, 415.353.2437